He was born to the painter Jan Portielje and his wife Eulalie (née Lemaire, 1828–1903).
From 1877 to 1881, he was a full-time student at the academy under the tutelage of Polydore Beaufaux, Charles Verlat and Nicaise de Keyser.
Many of his works are a series of similar interior scenes, created according to the wishes of his agents, Albert D'Huyvetter [nl] and Guillaume Campo (1880–1952).
These generally consist of a room with a sunny window, occupied by women in traditional costume, engaged in some daily activity.
In 1894, he worked together with Edouard de Jans and Joseph Dierickx to create murals for the Exposition Internationale d'Anvers.