The team currently competes in the Super League 2, the second tier of Greek football and it holds home matches at Stavros Mavrothalassitis Stadium.

Egaleo was founded in 1931 by Demetrios Haniotis and Georgios Aronis, as Athletic Union of Ierapolis (Αθλητική Ένωση Ιεραπόλεως – Athlitiki Enosis Ieropoleos).

In the 2003–04 season, Egaleo managed its second better ever classification, fifth (fourth in the 1970–71 season), playing UEFA Cup for the first time in 2004–05, appearing in the group stages (after defeating Gençlerbirliği of Turkey 2–1 score on aggregate) with FK Partizan, S.S. Lazio, Middlesbrough and Villarreal CF, which ended with the conquest of just one point.

At the end of the 2009–10 season, due to the merger being declared illegal by the Greek Council of State, Egaleo FC was relegated to the Delta Ethniki.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.