Eicosanoids, a diverse family of signaling molecules, are produced by oxygenation of polyunsaturated eicosatetraenoic acids.
[3] ETA is found in green-lipped mussel and appears to inhibit the oxygenation of arachidonic acid by both the cyclooxygenase (COX) and lipoxygenase pathways.
[4] Mutant of Mortierella alpina 1S-4 is a fungus employed for producing arachidonic acid.
These mutants produce larger amounts of ETA due to the expression of an ω-3-desaturase gene, typically responsible for the significant production of the more abundant PUFAs.
[5] In addition to their inflammatory nature, eicosanoids such as ETA can also contribute to an anti-inflammatory response.