The halt of Eisenach-West was opened on 1 August 1893 at the urging of the Eisenacher Kammgarnspinnerei (Eisenach Worsted Spinning Mill), at that time the largest industrial enterprise in the city, in the immediate vicinity of the main western entrance to the company premises.

At the same time, it was necessary to raise the tracks by up to 4 m in order to be able to remove the numerous level crossings in the urban area.

During the First World War, Eisenach-West was upgraded during a reorganisation of the hierarchy of railway operations (the introduction of military express trains) to allow the substantial dismantling of the marshalling yard of Eisenach station.

During the fighting at the end of the Second World War, the railway bridge across Kasseler Straße, which is immediately west of the station, was demolished and the rail traffic stopped for a few weeks.

The listed station consists of two buildings, which are interconnected by a passenger subway underneath the tracks, thus enabling rapid access between the two platforms.

A small waiting room and the ticket counter was on the ground floor and the sometimes covered platform for trains running to Erfurt was reached via steps.

On the upper floor, there were staff offices, signalling and other technical apparatus; today this area is a storage room.

The railway platform towards Gerstungen was connected to the waiting area and the ticket counter via a narrow subway.