He founded and directed literary magazines and wrote a variety of works: criticism, lyrical and dramatic poetry, essays, and biographies.

His most renowned dramatic work, El Palacio de Medrano, is a tragedy set in the colonial era, ending with the death of all its protagonists—whether by suicide, murder, or grief—without exception.

The tension escalates when Don Sebastián de Oviedo, a seemingly pious man who secretly harbors feelings for María, interrupts their conversation.

The act ends with a tense confrontation where her father insists on María's entrance to the convent, while Don Juan de Medrano tries to console his sister.

In the ensuing struggle, Ramiro kills Oviedo in self-defense but is unable to escape due to the timely arrival of President Don Álvaro de Medrano and his men.

However, Don Álvaro de Medrano, her father, remains resolute in his decision to send María to the convent, despite her heartfelt pleas and the revelation of her love for Ramiro.

Resigned to her destiny, María prays for mercy and, unable to bear the thought of a life in the convent without Ramiro, decides to take drastic measures.

The final scene is one of profound tragedy, followed by the devastating consequences of misplaced honor, unyielding societal expectations, and the destructive power of unfulfilled love.

"[6] According to the author José T. Laris, the palace of Medrano in Guadalajara, Mexico, was home to a noble family who had arranged a marriage of convenience for one of the daughters.

The frightened groom disappeared into the shadows of the night, and the heartbroken woman ran to the courtyard, tightly gripping a rope around her neck, ending her life by hanging herself.

Following Independence, it remained closed for many years; later, it was gradually repurposed as a barracks, inn, and alcaicería until it was auctioned and converted into the properties seen in that place today.

This massive mansion, constructed on the eastern bank of the San Juan de Dios River, was once on the city's outskirts, marking the end of the town of Analco.

However, following Oñate's death in Zacatecas in 1567, the palace was left uninhabited and shortly after fell into the hands of the Oidor Don Francisco de Medrano y Pacheco, who rebuilt it between 1640 and 1642.

[6] The Palace of Medrano, with its solid adobe and stone construction and large arches, was an architectural gem that adapted to the climate and human activities of its time.

The dignified and beautiful structure provided valuable lessons in architectural integrity and historical preservation, raising questions about the lasting value and quality of modern constructions.