Her first appearance was in a Greek romance series, titled "Alithines Istories", alongside Giorgos Kimoulis and Martha Karagianni in 1984.
In 1991 she did her break through as the nervous but caring operator in the Greek sitcom To Retire.
After a couple more comedy sitcoms, Panopoulou started to present her own show in the public television.
Panopoulou starred in two more series; "An Thimitheis to Oneiro Mou" and "Jenny kai Evanthia".
In 2007, she did a guest appearance on the popular Greek sitcom To Kokkino Domatio, aired on Mega.