She was the third daughter of King Charles II of Naples and Mary of Hungary.

[1] Eleanor was firstly married in 1299 to Philippe II de Toucy, son of Narjot de Toucy, Lord of Laterza, and Lucia of Tripoli.

On 17 May 1302, Eleanor married secondly to the King of Sicily, Frederick II.

[2] Her father and her new husband had been engaged in a war for ascendancy in the Mediterranean Sea and especially Sicily and the Mezzogiorno.

Thus, the peace was formal recognition of an uneasy status quo.