[1][2] Born in Genoa, Italy, Pozzi started to study acting during her high school years at the Teatro Stabile di Genova.

[1][3] She gave her debut on stage at the age of seventeen, playing the role of Romilda in an adaptation of Luigi Pirandello's The Late Mattia Pascal directed by Giorgio Albertazzi.

[3] Pozzi soon asserted herself as one of the most requested actresses of Italian theatre, notably working with Luca Ronconi, Peter Stein, Luigi Squarzina, Nanni Loy, Giancarlo Cobelli and at the Piccolo Teatro in Milan.

In 1992, her role of Adriana in Carlo Verdone's Damned the Day I Met You earned her the David di Donatello Award for Best Supporting Actress.

[3][4] In 2002, she played the title role of Hamlet in a production in the Teatro Farnese in Parma, directed by Walter Le Moli.