Her films include Italian Race (2016) and Rose Island (2020), for which she won a David di Donatello and a Nastri d'Argento.

[9][10] In 2018, she starred in the drama film Youtopia, where she played a teenage girl selling her virginity online in order to save her family.

[3][11][12] In 2020, she was in the main cast of the HBO television miniseries The Undoing[2] and starred in the Netflix original film Rose Island, directed by Sydney Sibilia.

[16] In 2022 she acted in Robbing Mussolini and starred alongside Liev Schreiber in the film adaptation of Ernest Hemingway's novel with the same name Across the River and into the Trees.

[17] The same year she collaborated on the third single "Litoranea" from Elisa's studio album Ritorno al futuro/Back to the Future, being De Angelis first certified song by FIMI.