In the 1910s González enjoyed political success as he was elected as a National Deputy for the city of Buenos Aires in 1912, and later, for the Province of Córdoba in 1916.

In 1922 he was elected vice president on the Marcelo T. de Alvear ticket (1922-1928), after defeating a conservative party alliance called the Concertación Nacional.

During his administration he opposed the president on many issues as part of a conflict between Yrigoyen's followers and the Antipersonalist faction of the Radical Union.

In 1928 during Yrigoyen's second administration (1928-1930) he served as Interior Minister until the military coup of September 6, 1930, which led to his incarceration for two years.

He refused to receive the pension as vice president of the nation and in his last years, he worked as a seller for Anilinas Colibrí company.