In 2007, while processing microwave space data (radar imagery), she discovered an ancient Mega-Lake (30,750 km2) buried beneath the sand of the Great Sahara in Northern Darfur, Sudan.
Ghoneim's findings suggest that this branch was suitably sized to act as a transportation waterway for workmen and building materials to the pyramids’ sites.
In 2010, she joined the Department of Earth and Ocean Sciences at the University of North Carolina Wilmington (UNCW) and became the director of the Space and Drone Remote Sensing Lab (SDRS).
She has a primary focus on the application of geographic information system (GIS), remote sensing (including multispectral, thermal and microwave radar imagery), unmanned aerial vehicle (UAV) and the use of hydrologic modeling in flash flood hazard, sea level rise, drought and groundwater exploration in arid and coastal environments.
[6][7] Additionally, her work in topography mapping leverages high-resolution satellite data, such as Sentinel-2 and Landsat, to chart the Nile Valley's features and trace ancient river systems potentially linked to early civilizations.