She is known for playing Sloan McQuewick on HBO's Entourage (2004–11), Claire Bonner in Snow Day (2000), Dalia in You Don't Mess with the Zohan (2008), Lorelei Martins on CBS's The Mentalist (2008–15), and Lana Lang on The CW's Superman & Lois (2021–24).

She had a larger role in Chris Koch's teen comedy Snow Day (2000) portraying Claire Bonner, and then appeared in several other Hollywood films, such as 100 Girls, Wrong Turn, On the Line, and In the Mix.

[17] Chriqui also starred in several music videos including Hinder's "Lips of an Angel", Zac Brown Band's "Whatever It Is", and Charles Perry's "I Could Be the Best Time of Your Life".

From the second season to the end of the show's original run, Chriqui played Sloan McQuewick in the hit HBO series Entourage.

In April 2020, Chriqui was cast as Lana Lang in the CW action-superhero series Superman & Lois, and also portrayed her Bizarro counterpart Lana-Rho in the second season.

"[25] On 12 October, she signed an open letter by Creative Community for Peace denouncing the attacks and calling for the return of kidnapped Israelis.

[26] On 14 February 2024, Chriqui signed another letter by the organization that criticized attempts to remove Israel from Eurovision 2024 due to the Israel-Hamas war.