Enarotali Nature Reserve is a protected area in Central Papua Province of Western (Indonesian) New Guinea.

The western portion of the reserve covers the eastern end of the Weyland Mountains, and it abuts Weyland Mountains Nature Reserve.

The center of the reserve surrounds, but does not include, the Paniai Lakes.

The eastern portion of the reserve extends to the western end of the Sudirman Range.

Most of the reserve is covered in montane rain forest.