[4] The disease, enzootic nasal adenocarcinoma is common in North America and is found in sheep and goats on every continent except New Zealand and Australia.

[6][7] In the future, research on ENTV may become important in studying viruses that cause human lung cancer.

Tumors form in the upper nasal cavity and have a gelatinous consistency with caudal areas being having hemorrhage causing a brownish-red color.

[12] However, recent studies have shown that there is sero-conversion in response to the envelope protein if a host is exposed to the virus after a long period of time.

[13] The lack of an extensive immune response may be due to the face that a large portion of the ovine genome is made up of sequences that are related to the retroviruses JSRV and ENTV.

The 3’ end of env and the U3 LTR region contain amino acids with the least similarity making these areas important in scientific studies.

It is thought that this difference in the Env TM cytoplasmic tail is important in the spreading of the virus to host species.

Inside the pol gene is an open reading frame, Orf-x which is abnormal for simple retroviruses.

It encodes surface and transmembrane envelope proteins by being cleaved twice, a polypeptide precursor, and a hydrophobic region.

[7] The low pH is beneficial to the virus by creating a tumor prone environment that activates HA degradation enzymes.

[15] The TM subunit of the env gene plays an important role in the entry of ENTV into a cell.

[2]  The SU subunit of the env gene also plays an important role in cell entry by influencing the low pH-dependent fusion activity.