Ephraim L. Van Winkle (July 20, 1827 – May 23, 1866) was an American politician who served as Secretary of State of Kentucky from 1863 until his death in 1866.

[1] After graduating, Van Winkle began practicing law in Wayne County.

In 1860, Van Winkle was a Presidential elector for the John Bell and Edward Everett slate.

[1] In 1863, Van Winkle was appointed Secretary of State of Kentucky by governor Thomas E.

His position as Secretary of State of Kentucky was filled by his brother John S. Van Winkle.