As of November 3, 2020, Wayne County is a wet county—a measure allowing the sales and consumption of alcoholic drinks passed by a margin of 4,901 for and 3,966 against.

Many Revolutionary War veterans followed Price, including Joshua Jones, who arrived in 1794, Jonathan and James Ingram in 1796, Cornelius Phillips in 1798, and Isaac West in 1799.

Veterans, they had each been given land grants in the area, in lieu of back salary payments by the United States government from the war.

It was the 43rd county in the state and is named for General "Mad Anthony" Wayne, a hero of the American Revolution and the Northwest Indian War.

[6] Wayne's victory at the Battle of Fallen Timbers virtually ended the Indian threat against Kentucky settlers.

Early in the Civil War, Confederate Army General Felix Zollicoffer made his headquarters in the Brown-Lanier House at Mill Springs.

Wayne County observed Central time until October 2000; an account of this change is documented in an article by Dr. Stanley Brunn of the University of Kentucky.

Its name has changed several times during that period; it is presently knows as Wayne County Area Technology Center (ATC).

Programs include Health Science, Welding, Carpentry, Machine Tool, Automotive, Industrial Maintenance, and Business.