[1] It generally presents with scaly spots and small bumps particularly on the hands, feet, face, and neck; typically beginning in childhood or a young adult.

[1] On the trunk, it typically appears like pityriasis versicolor; lesions are slightly scaly and tan, brown, red, or looking pale.

[1] Medications used to treat the lesions include ALA-PDT (photodynamic therapy with aminolevulinic acid), applying 5-FU, imiquimod, and retinoids by mouth.

[8] Patients present with flat, slightly scaly, red-brown macules on the face, neck, and body, recurring especially around the penial area, or verruca-like papillomatous lesions, seborrheic keratosis-like lesions, and pinkish-red plane papules on the hands, upper and lower extremities, and face.

[citation needed] Cimetidine was reported to be effective because of its depressing mitogen-induced lymphocyte proliferation and regulatory T cell activity features.

[15] A patient of dermatologist Carmen Madeleine Curea, his pictures appeared on numerous blogs and Romanian press sources.

[20] The Discovery Channel funded a blood analysis and found he lacked an immune system antigen to fight yeast infection.

[citation needed] According to The Jakarta Post, Koswara underwent the first of a series of new surgical procedures to remove the regrown warts in the spring of 2011.

At the end of December 2010, two doctors from the Japanese Society for Complementary and Alternative Medicine brought him a drug made from Job's tears.

[citation needed] Koswara died on 30 January 2016 at Hasan Sadikin Hospital, Bandung, from the complications related to his condition.

[citation needed] In January 2016, a 25-year-old patient named Abul Bajandar from Khulna, Bangladesh was admitted to Dhaka Medical College and Hospital and was diagnosed with this condition.

[28] As of July 2023, doctors had refused amputation as a solution and insisted on continuous minor surgeries to manage the condition, which would be provided free of charge by the Bangladeshi government.

[29] In January 2017, it was reported that a 10-year-old girl in Bangladesh, Sahana Khatun, was diagnosed after developing lesions four months earlier.

[30] In August 2017, it was reported that a 42-year-old man from Gaza, Mohammed Taluli, had been successfully operated on at the Hadassah Medical Centre in Jerusalem.

[32] Sebastian Quinn is a Pittsburgh man with the condition who featured as a patient on an episode of TLC's My Feet Are Killing Me in January 2021.