[4] Established in 1929, Epsilon Sigma Alpha is a network of an estimated 10,000 members in over 1,000 community-based chapters, with coordinating organizations at state and international levels.

[6] She asked prominent women from around the United States to serve as members of the Founder's Chapter and to act as advisors.

[6] The Founders Chapter included:[6] The society's first national headquarters was located in Kansas City, Missouri, with a central states divisional office in St. Louis.

Since then, Epsilon Sigma Alpha chapters have been organized in Germany, Guam, Denmark, Peru, Australia, Mexico, the Philippines, and Scotland.

A streamlined logo was adopted during a brand refresh, consisting of three joined circles surrounding the three English letters representing the name of the society.

As of July 2006, ΕΣΑ had raised over 100 million dollars for St. Jude's Children's Research Hospital, meeting an organization goal for their 75th anniversary.

[12] ΕΣΑ has endowed the St. Jude Bone Marrow Transplant area in the hospital's Patient Care Center and the fourth floor of the ALSAC Tower.

Each year, members help raise millions of dollars for philanthropic projects and give an estimated 650,000 hours of personal service.

In addition, the ΕΣΑ Foundation supports education through an ongoing Scholarship/Endowment Program and provides grants to individuals involved in charitable service for children and adults.