[19] Head coach Chip Kelly named Rowe the third cornerback on the Eagles' depth chart to begin the regular season, behind Byron Maxwell and Nolan Carroll.

On December 6, 2015, Rowe earned his first career start in place of Nolan Carroll who was inactive after breaking his ankle the previous week.

[24][25] On January 18, 2016, the Eagles hired Kansas City Chiefs offensive coordinator Doug Pederson as their new head coach.

[26] During training camp, Rowe competed to be a starting cornerback against Nolan Carroll, Leodis McKelvin, Jalen Mills, and Ron Brooks.

[28] Head coach Bill Belichick named Rowe the fifth cornerback on the depth chart, behind Logan Ryan, Malcolm Butler, Justin Coleman, and Cyrus Jones.

[30] In Week 7, he earned his first start as a member of the Patriots and recorded a season-high six combined tackles and broke up a pass during a 27–16 win at the Pittsburgh Steelers.

[34] On January 14, 2017, Rowe appeared in his first career playoff game and recorded three solo tackles during a 34–16 win against the Houston Texans in the AFC Divisional Round.

The game featured the largest comeback in Super Bowl history as the Patriots trailed the Falcons by 25 points in the third quarter.

[37] Head coach Bill Belichick named Rowe the third cornerback on the Patriots' depth chart to start the regular season, behind Stephon Gilmore and Malcolm Butler.

[41] Due to injuries, Rowe was limited to only eight games and three starts in 2017 and only recorded 15 combined tackles (14 solo) and two pass deflections.

[25][42] The Patriots finished atop the AFC East with a 13–3 record in 2017, which earned them a first round bye and home-field advantage throughout the playoffs.

On January 13, 2018, Rowe started his first career playoff game and made five combined tackles as the Patriots defeated the Tennessee Titans 35–14 in the AFC Divisional Round.

The coaching decision was heavily criticized among media and NFL analysts as Butler started throughout the entire season and was a key player in their Super Bowl XLIX and LI victories.

The Eagles were planning to exploit a mismatch and predicted Rowe would have difficulty covering wide receiver Alshon Jeffery.

[52][53] In week 17 against the New England Patriots, Rowe intercepted a pass thrown by former teammate Tom Brady and returned it for a 35-yard pick six during the 27–24 win.

[54] In Week 8 against the Los Angeles Rams, Rowe recorded his first interception of the season off a pass thrown by Jared Goff during the 28–17 win.