During the Second International Polar Year, 1932–3, he led a Canadian expedition to Meanook, which lies in the northern part of Alberta.
In 1947, E. H. Vestine et al. produced a comprehensive, two-volume work detailing all the geomagnetic data of the department.
In addition to his research into geomagnetics, he collaborated with studies into seismology and cosmic rays.
There he performed studies on planetary and space science, as well as issues concerning national security.
His son, Henry Vestine, became a famous guitarist, playing with Frank Zappa's The Mothers of Invention and Canned Heat.