Eugene Pierce Gillespie (September 24, 1852 – December 16, 1899) was a Democratic member of the U.S. House of Representatives from Pennsylvania.

He attended the public schools, Allegheny College in Meadville, Pennsylvania, and St. Michael's College in Toronto, Ontario, Canada.

He studied law, was admitted to the bar in August 1874 and began his legal practice in Greenville.

[3][4] Gillespie was elected as a Democrat to the Fifty-second Congress.

[5][6] He continued the practice of law until his death on December 16, 1899.