Eugenia calycina is native to Brazil, including but not exclusive to the states of Goiás, São Paulo, Minas Gerais, Mato Grosso do Sul, and Paraná.

[2] It grows wild in savannahs and fields up to 1,600 meters (5,200 feet) in elevation, especially in drier areas.

There are at least two pointed, cordate-based, ovate bracts measuring 0.9–2.2 centimeters (0.35–0.87 inches) in length at the base of each fruit.

Seedling growth is rapid, with the plant often reaching 20 centimeters (7.9 inches) at 10 months of age.

The plant prefers positions in full sun or partial shade and tolerates semi-arid, rainy temperate, and subtropical to tropical dry and wet climates.

This indicates that the essential oil of Eugenia calycina shows high activity against the larvae of Aedes aegypti but has lower cytotoxicity against mammalian cells.

The total phenolic content in the leaves, pulp, and seed is 20371.96, 7139.70, and 2204.75 μg/g dw, with the main compounds being ellagic acid, myricitrin, and epicatechin gallate.