European route E65 is a north-south Class-A European route that begins in Malmö, Sweden and ends in Chania, Greece.

The road is about 4,400 km (2,700 mi) in length.

Formerly, before 1985, this was the E14.

In Greece, the E65 will be rerouted between Kozani and Lamia when the A3 motorway is completed: the revised route will follow the A2 motorway (Egnatia Odos) towards Kipoureio, and then the A3 itself towards Anthili via Trikala.

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