Eusebio Guilarte Mole (15 October 1805 – 11 June 1849) was a Bolivian military officer and statesman who served as the tenth president of Bolivia from 1847 to 1848.

A career military officer (not an uncommon choice at the time), Guilarte had fought under Andrés de Santa Cruz at Zepita, and also in the battles of the War of the Confederation (Yanacocha and Uchumayo, among others).

He had been José Ballivián's deputy aide at the Battle of Ingavi, for which he was rewarded as Ambassador to Brazil.

Allowed to live under house arrest in internal exile at the Pacific port of Cobija, Litoral, Guilarte was assassinated less than two years later after attempting to stage a coup, in 1849.

After one of his own officers gave away the plot, Guilarte was executed by orders of the military governor of the region, who was allied to Belzu.