Maydell was first elected to the European Parliament in 2014 at age 28, the youngest member of the EPP Group at the time.

One of the organization's main goals is to reduce functional illiteracy by 2030 and to modernize the Bulgarian educational curriculum.

[12][13] In this role, Maydell hosts pan-European conferences, meetings, and initiatives that promote European unity and attempt to tackle some of Europe's biggest problems.

[14] Maydell is the initiator of the yearly "Regulation4Innovation" conference in Brussels which brings together experts and businesspeople in the field of technology to discuss the latest developments in the sector.

[15] Maydell is a board member of the World Economic Forum's Digital Leaders of Europe, which seeks to develop and foster a Pan-European ecosystem by building bridges between founders, investors, and incubators as well as public figures and corporate representatives.

[28] In 2018, the Financial Times' named her among the "Top 100 Most Influential Persons in Central and Eastern Europe",[29] and Politico's among the "Women who shape Brussels".