Between 2013 and January 2015 she has been serving as Deputy Minister of Education, Lifelong learning and Religions in the Greek Ministry of Interior and Administrative Reconstruction.

From 2004 until December 2006, Evi Christofilopoulou was the co-ordinator for Civil Cases in the Parliamentary Team of the Panhellenic Socialist Movement.

She has been a member of the Committee of the program of the Panhellenic Socialist Movement in charge for the policies related to the family and children.

In March 2004, she was elected as a member of the Hellenic Parliament with the Panhellenic Socialist Movement in the Prefecture of Attica (greater Athens).

In October 2009, she was re-elected as a member of the Hellenic Parliament and was appointed as the Deputy Minister of Education, Lifelong learning and Religions in the Cabinet of George Papandreou, which she remained in the Papademos.