Expedition 22 was the twenty-second long duration crew flight to the International Space Station (ISS).

For a period of three weeks, there were only two crew members; it was the first time that had occurred since STS-114.

Commander Jeff Williams and flight engineer Maksim Surayev were joined by the rest of their crew on 22 December 2009, making the Expedition 22 a crew of five.

[1] The expedition had ended when Soyuz TMA-16 undocked on 18 March 2010, and was immediately followed by the start of Expedition 23.

[2] This article incorporates public domain material from websites or documents of the National Aeronautics and Space Administration.