Expedition 45 was the 45th expedition to the International Space Station.

Scott Kelly and Mikhail Korniyenko transferred from Expedition 44 as part of their year-long stay aboard the ISS.

Expedition 45 began with the departure of Soyuz TMA-16M at the ISS on September 11, 2015 and concluded with the departure of Soyuz TMA-17M on December 11, 2015.

Kelly, Korniyenko, and Sergey Volkov then transferred to the crew of Expedition 46.

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