Agamotto, a powerful mystic being and one of Doctor Strange's three Vishanti,[6] is said to have used the Eye during his time as Sorcerer Supreme of the Earth dimension.

Doom claims the object must belong to him, for the protection of others, but abandons the Eye after using it to see his future, informing Brother Voodoo that he will gain nothing from it.

[13] The entity that has possessed him subsequently 'jumping' into Iron Fist, who then teleports away with the Eye, triggering a rift in the sky that Strange states means the end of everything.

[14] As the Avengers battle the demons back on Earth, Iron Fist finds himself in a white void where he encounters the Ancient One, who claims that he is responsible for the current invasion due to his anger at Strange's recent 'failures'.

[17][18] Although the group attempt to defeat Agamotto by empowering Wolverine to serve as their 'avatar', Doctor Voodoo is finally forced to sacrifice himself to contain their foe, apparently destroying himself and the Eye at the same time.

Set a hundred years in the future, after a nuclear war, the cloak, tattered, and the Eye are among the many artifacts in the memorial room in the home of Rick Jones.

[22] The Eye of Agamotto can radiate mystical light that enables the user to see through disguises and illusions,[23][24] see past events, and track ethereal and corporeal beings by their energy.

Additionally, the Eye can probe the minds of others, project mystical shields, create portals to other dimensions, levitate the user, and place others in suspended animation.

[27][28] The "Eye of Agamoto" is referenced in the eponymous Don Preston song, which is included on the album Grandmothers by Rhino Records.