FC Dnipro-2 (Ukrainian: ФК Дніпро-2) was the reserve team of FC Dnipro.

The club initially competed in the Dnipropetrovsk Oblast competition as FC Dnipro-2 Dnipropetrovsk .

In 1997 the club was entered into the professional leagues to compete in the Second League.

In 2004, when the PFL organised a competition for reserve teams of Premier League clubs the club moved into that competition.

In 2010 the club was entered as Dnipro's third team in the professional leagues as Dnipro-2.