Most of the faculty's facilities are located at Pabellón III of the Ciudad Universitaria complex, the UBA's only centralized campus, in the Buenos Aires neighborhood of Núñez.

The department of architecture was in the beginning part of the Faculty of Exact, Physical, and Natural Sciences, which had its seat at the Manzana de las Luces complex, in Downtown Buenos Aires.

In its early years, the Escuela de Arquitectura was heavily influenced by French schools of architecture, following the cues of Paris' École des beaux-arts.

[3] In 1966, the Faculty moved to its current seat in the Ciudad Universitaria complex, a purpose-built campus which originally intended to house most (if not all) UBA dependencies.

During the dictatorship, the faculty's handpicked dean was professor Héctor Corbacho, who taught technical drawing at the Navy's Escuela de Mecánica (ESMA).

[14] Other known UBA-educated architects include Claudio Vekstein, organic architecture proponent Patricio Pouchulu, and the Uruguayan Rafael Viñoly, who designed the Cero+infinito building at Ciudad Universitaria, completed in 2021.