It is the sixth oldest medical school in Thailand located in Hat Yai District, Songkhla Province and is the fourth oldest faculty of Prince of Songkla University, opening in 1972 by royal decree.

[1] Due to a lack of medical and healthcare personnel in Thailand, as well as various healthcare issues in Southern Thailand, the council of Prince of Songkla University requested for the construction of a Faculty of Medicine on 11 September 1968.

The project was approved on 17 August 1971 and construction began at the Hat Yai campus of the university.

[2] On 26 August 1976, King Bhumibol Adulyadej and Queen Sirikit laid the foundation for the construction of the faculty's main teaching hospital.

The following table displays the programs taught at the Faculty of Medicine at Prince of Songkla University.