The highway travels in a southern direction along the eastern edge of the town, leaving the city limits near County Road 5223.

FM 2200 generally runs in a southern direction through rural farming areas, turning east at County Road 731.

After leaving Yancey, FM 2200 mostly runs in an eastern direction towards Devine, ending at an intersection with SH 173.

A previous route numbered FM 2200 was designated on October 29, 1953, traveling from SH 123 near Stockdale, southwestward to a road intersection at a distance of 5.9 miles (9.5 km).

FM 2201 continues to travel in a mostly eastern direction through rural farming areas, ending at an intersection with US 281 just north of I-20.

The highway travels in a northern direction through rural farming and ranching areas, ending at an intersection with FM 119 near the North Plains Country Club.

Known locally as Harrison Road, it runs from SH 42 near White Oak east to Loop 281 in Longview.

FM 2210 was designated on October 28, 1953, traveling from SH 199 southward to Gibtown at a distance of 3.0 miles (4.8 km).

The highway was extended 13.4 miles (21.6 km) to a road intersection northwest of Perrin on October 3, 1961, absorbing all of FM 2350.

It runs about 1.3 miles (2.1 km) within Berryville, from SH 155 north of Frankston eastward to CR 4117, near the western shore of Lake Palestine.

On the outskirts of Pleak, FM 2218 curves north, then it turns north-northeast near the Meadow Bend Park Estates subdivision.

[51] A previous route numbered FM 2225 was designated on September 29, 1954, from SH 25 near Archer City to a point 5.9 miles (9.5 km) southeast.

FM 2225 was cancelled on July 18, 1958, and removed from the highway system as the county could not acquire right-of-way for the route.

FM 2227 was designated on September 29, 1954, running from US 80 (now BL I-20) in Odessa southward to SH 51 (now US 385) at a distance of 3.7 miles (6.0 km).

The second route numbered FM 2233 was designated on September 20, 1961, running from SH 174 northwestward to the Tarrant County line at a distance of 2.2 miles (3.5 km).

[65] Farm to Market Road 2234 (FM 2234) is an urban and suburban route between Missouri City and Pearland, south-southwest of Houston.

Beginning at US 90 Alt., the road follows a southerly path through neighborhoods of Missouri City, in Fort Bend County, passing briefly through Stafford.

After making an east curve, FM 2234 passes briefly through Houston and then crosses under the Fort Bend Parkway.

The highway travels in an eastern direction through a suburban area, passing Pleasant Grove Middle School and the First Baptist Church, ending at an intersection with FM 1397.

[81][84] RM 2243 was first designated on September 29, 1954, as Farm to Market Road 2243 (FM 2243), connecting US 183 in Leander to US 81 (later replaced by I-35 Business) in Georgetown.

The segment west of US 183 was removed from the state highway system and returned to the city of Leander's jurisdiction on April 24, 2003.

It crosses the controlled-access portion of Wurzbach Parkway, and turns to the northeast, where the route becomes Nacogdoches Road.

The highway runs east, meeting FM 179 (Inler Avenue) at a stop sign-controlled intersection.

FM 2255 was designated on September 21, 1955, from War Highway 5 (now Spur 309) east to west Lubbock City Limits.

[117] A previous route numbered FM 2256 was designated on October 13, 1954, from SH 154 southeast of Harleton northeast 13.2 miles (21.2 km) to US 59 south of Jefferson.

A previous route numbered FM 2257 was designated on October 13, 1954, from SH 150 at Waverly southeast 4.2 miles (6.8 km) to a road intersection.

A previous route numbered FM 2270 was designated on October 25, 1954, from SH 95, south of Holland, east 7.3 miles (11.7 km) to Vilas.

The road begins at US 183 south of May, and continues west until it reaches FM 2559 northeast of Grosvenor, where it subsequently changes numbers.

The highway begins at Hebron Parkway in Carrollton and runs north to the Sam Rayburn Tollway in Lewisville.

The highway crosses over the North Concho River and enters the town of Grape Creek, ending at a junction with US 87.