US 67 is part of the La Entrada al Pacifico international trade corridor from its southern terminus to US 385 in McCamey.

US 67 travels through mostly rural areas, passing through or near the towns of Rankin, Big Lake, and Mertzon.

US 67 leaves Stephenville and travels to Glen Rose, the location of Dinosaur Valley State Park.

US 67 then travels to Cleburne, bypassing the town on a four lane freeway; the bypass is known as Walter P. Holliday Drive from US 67 Business near Lake Pat Cleburne to FM 4, while the remainder is known as Catherine P. Raines Drive.

The two highways travel through east Dallas, Mesquite, and Garland, Texas before crossing over Lake Ray Hubbard, twice.

US 67 travels on the south border of the Lone Star Army Ammunition Plant, before arriving in Texarkana.

US 67 has business routes in Presidio, two in San Angelo, Cleburne, Alvarado, and Sulphur Springs.