He has collaborated with artists such as Pitbull, Daddy Yankee, Don Omar, Arcángel, Ñengo Flow, Bad Bunny and Yandel.

Farruko released his first song "Sexo Fuera Del Planeta" in 2009 through the Internet and gained fame in Puerto Rico.

Farruko released his first album El Talento Del Bloque which produced hit singles, "Su Hija Me Gusta" featuring José Feliciano, "Nena Fichu", and "Te Iré a Buscar".

His second album, released in 2012, featured collaborations with Puerto Rican superstar Daddy Yankee, and Cuban star Micha.

The smash hit was "Besas Tan Bien" and "Mi Vida No Va a Cambiar" alongside Arcángel which was not a single on the album.