It was originally released on June 23, 2017, through Sony Music, as the lead single from Mateo's fifth studio album, A Cámara Lenta.

[6] On October 26, 2017, Mateo performed the song with Farruko and Christian Daniel during the 2017 Latin American Music Awards at Dolby Theatre in Hollywood, California.

[7] On November 4, 2017, Mateo performed "Loco Enamorado" at a sold-out Luna Park Stadium, in Buenos Aires, Argentina.

[8] On November 5, 2017, Mateo and Farruko performed the song in front of 60,000 people during the 2017 Festival Presidente at Estadio Olímpico Félix Sánchez in the Dominican Republic.

[8] On November 8, 2017, Mateo sang "Loco Enamorado" during the 2017 Telehit Awards at Palacio de los Deportes in Mexico City.