As his songs grew in popularity online, Puerto Rican radio stations picked up on the internet hype and began to broadcast Farruko to a wider audience, solidifying his presence in the reggaeton scene.

He has been the lead singer or featured on top performing songs including "Krippy Kush", "Inolvidable", "Quiéreme", and "Calma" (remix).

[5] Farruko has collaborated with many artists including Bad Bunny,[6] J Balvin, Nicki Minaj, Travis Scott, Ricky Martin, and Wisin & Yandel.

On February 12, 2022, during a performance at the FTX Arena in Miami, Farruko stopped the concert to give a speech, in which he devoted himself to preaching about God, expressing his problems and asking forgiveness for the lyrics of some of his songs.

On April 3, 2018, Farruko was arrested in Puerto Rico, accused of hiding $52,000 in undeclared cash in shoes and luggage when returning from the Dominican Republic for which he was required to do three years of probation.