In 2010, he released his first studio album El Talento del Bloque, followed by The Most Powerful Rookie in 2012 and Farruko Presenta: Los Menores in 2014, the latter two were nominated for the Latin Grammy Award for Best Urban Music Album.

In 2013, he achieved significant commercial success with the song "6 AM", alongside Colombian singer J Balvin, the song won Urban Song of the Year and Urban Collaboration of the Year at the Premio Lo Nuestro 2015 and received two Latin Grammy Award nominations.

In 2016, he won the Latin Grammy Award for Best Urban Song as one of the songwriters of Yandel's "Encantado".

His following albums were TrapXficante (2017), Gangalee (2019), and En Letra de Otro (2019).

In 2018, he participated in the remix for Pedro Capó's "Calma", the song was a huge commercial success and received various awards and nominations, it was nominated for six Billboard Latin Music Awards winning Latin Pop Song of the Year, it also won the Latin Grammy Award for Best Urban Fusion/Performance.