Losco has released six studio albums so far in her career and is one of the most successful Maltese musicians of all time.

She has appeared in front of audiences ranging from 1,000 to 80,000, and has played alongside renowned international acts such as Elton John, Katie Melua, Maroon 5, Akon, Melanie C, Ronan Keating, Bob Geldof, Tokio Hotel and Gigi D'Alessio.

[4] Losco has been involved in advertising in her country, including for Guess, McDonald's Salad Plus,[5] and Vodafone's Music Jam Campaign.

She finished runner up, just 12 points behind eventual winner Marie N, which was Malta's highest result ever in the competition until it was equalled in 2005.

The national final rules, set by PBS, allow for the winning song to be partially modified or completely changed.

On 19 February 2016, PBS announced that an international jury consisting of representatives from ten countries, along with local experts from Malta, would be presented with several songs, including a revamped version of "Chameleon", and would determine which song Losco would perform at the contest.

[11][12][13] The dress she wore for the contest was by Alex Zabotto-Bentley, who has also designed for Lady Gaga, Prince and Kylie Minogue.

[28] Losco has publicly expressed her support for a number of social causes in Malta, including LGBT rights and anti-bullying campaigns amongst teenagers.