[3] The A.22 was best known for its contribution to some world long distance record flights[2] made by the single engine landplane Savoia-Marchetti S.64, which used the specially adapted A.22 T. version.

Between 31 May and 2 June 1928 this aircraft flew non-stop for 7,665 km (4,763 mi) to capture the world closed circuit distance record.

[4] A month later, the same crew set a new world straight-line distance record of 7,187 km (4,467 mi), flying from Italy to Brazil in 47 hr 55 min.

The closed circuit record was later taken by the French but a slightly revised S.64bis recovered it for Italy with a distance of 8,187 km (5,088 mi) flown in 67 hr 13 min on 31 May-2 June 1930.

[4] The A.22R powered more conventional, airline, flights in a Savoia-Marchetti S.66 three engine flying boat operated by Ala Littoria on the Rome-Cagliari-Tripoli and Rome-Athens-Alexandria routes.