The title was still in use after Chile become a republic in the 19th century; the term, was slowly superseded by the newer First Lady, similar to the one used in other countries.

[a] Due to the complex evolution of the Head of State of Chile after the emancipation from Spain and the non-official character of the title, it is not possible to define who was the "first First Lady".

Potential options include: During the 19th and early 20th century, the First Lady was considered one of the most influential figures of Chilean high society.

In 1925, the First Lady had their own private office and staff, to support her role as the president of different charitable organizations created by the government.

Other foundations created by the First Ladies by the middle of the 20th century included the Ropero del Pueblo (1947–1958) and CEMA Chile (1967–1990).