The first lady of Florida is the hostess of the Florida Governor's Mansion, usually the spouse of the governor of Florida, concurrent with the governor's term in office.

Casey DeSantis is the current first lady of Florida, assuming the position on January 8, 2019, as the wife of 46th and current Florida governor Ron DeSantis, with whom she has three children.

Rhoda Elizabeth Waller Gibbes, the mother of Florida governor Albert Gilchrist, served as first lady of Florida from 1909 to 1912, and pushed for a monument to the American Civil War Battle of Olustee.

[1] In 2019, Casey DeSantis established the First Lady's Medal for Courage, Commitment, and Service.

[2]