First lady of Guinea (French: Première Dame de la République de Guinée) is the title attributed to the wife of the president of Guinea.

[1] The country's present first lady is Lauriane Doumbouya, wife of interim President Mamady Doumbouya, who had held the position since the 2021 Guinean coup d'etat on September 5, 2021.

[2] There has been no first gentleman of Guinea to date.