First Lady of Mozambique (Portuguese: Primeira-Dama de Moçambique[1]) is the title held by the wife of the president of Mozambique.

The country's current first lady is , wife of President , who has held the position since 2025.

The Office of the First Lady was established by Article 17 of the Internal Regulations Decree.

[1] The office is headed by a presidential cabinet member.

[2] She became the first lady of South Africa on 18 July 1998 upon her marriage to Nelson Mandela.