First Lady of Paraguay (Spanish: Primera Dama de Paraguay), also called First Lady of the Nation (Spanish: Primera Dama de la Nación), is the official post of the wife (or designated person) of the president of Paraguay.

The current first lady of Paraguay is Leticia Ocampos, wife of President Santiago Peña.

[2] According to Paraguayan law, the Office of the First Lady of the Nation depends structurally and financially on the presidency of the republic.

The first lady exercises her duties through the REPADEH (Red Paraguaya para el Desarrollo Humano) Foundation, focused mainly in social and health affairs.

With the exception of a 14-month period between 2012–2013, Paraguay did not have a president's wife as First Lady for a decade, between 2008 and 2018.