First Lady of Uruguay (Spanish: Primera Dama de Uruguay) is the unofficial and protocol title of the wife of the president of Uruguay, and hostess of Suarez Residence.

The first lady is not an elected position, carries no official duties and brings no salary, but is traditionally responsible for directing and coordinating activities in the social field of the presidency and also accompany the president in ceremonies or official activities.

The role is Vacant since the President Luis Lacalle Pou divorced his wife the First Lady Lorena Ponce de León in 17 June 2024.

(Spouse)