Flamingo was originally identified as a Drosophila protein involved in planar cell polarity.
In mice, all three have distinct expression patterns in organs such as the kidney, skin, and lungs, as well as the brain.
It has been extensively studied for its role in patterning developmental tissues in a wide range of species.
[4][6][7] In Drosophila, flamingo mutants were found to have abnormal dendrite branching, outgrowth and routing.
[9] A study of mammalian flamingo homolog CELSR2 found that it is involved in the regulation of dendrite growth.