5II079912311ENSG00000004948ENSMUSG00000023964P30988Q60755NM_001742NM_001164737NM_001164738NM_001042725NM_007588NM_001355192NM_001377018NP_001158209NP_001158210NP_001733NP_001036190NP_031614NP_001342121NP_001363947The calcitonin receptor (CT) is a G protein-coupled receptor that binds the peptide hormone calcitonin and is involved in maintenance of calcium homeostasis,[5] particularly with respect to bone formation and metabolism.

[6][7][8] CT works by activating the G-proteins Gs and Gq often found on osteoclasts, on cells in the kidney, and on cells in a number of regions of the brain.

[9] It may also affect the ovaries in women and the testes in men.

[10] Preclinical studies have suggested that dual amylin and calcitonin receptor agonists may be more effective than amylin receptor agonists for obesity and type II diabetes.

[11] Calcitonin receptor has been shown to interact with Apolipoprotein B[12][13] and LRP1.