Located in the Vão do Paranã statistical micro-region, Flores has boundaries with Buritis, Sítio d'Abadia, Vila Boa, Alvorada do Norte, Iaciara, Nova Roma, São João d'Aliança, Formosa and Alto Paraíso de Goiás.

Highway connections with Goiânia are made by BR-153 / Anápolis / GO-060 / Alexânia / Planaltina / Formosa / GO-020 / BR-030 / Vila Boa / GO-114.

[2] The Rio Paranã supplies much of the water for irrigation of the crops and filling up of small dams for livestock raising.

Other rivers of importance are: Macacos, Piripiri, Santa Maria, Corrente, Canabrava, Bonifácio, Gameleira and Macacão.

Other farmers from the south have planted irrigated rice, soybeans, and corn, but Flores is still known as cattle country.