[6] Beginning in the 1940s, Florida Sanitarium began using modern medicines, molecular diagnostic and surgical procedures.

[12][13][14] On October 21, 2020, 1,800 solar panel carport was installed at AdventHealth Orlando on top of its McRae parking garage.

[15][16][17] On January 1, 2021, the United States government passed a law requiring all hospitals to have their chargemaster on its website.

[19] On October 12, 2021, a construction crane collapsed onto a parking garage that was being built at the AdventHealth Orlando campus.

[23] In early February 2023, Loma Linda University School of Medicine partnered with AdventHealth Orlando, which will allow students to complete their third and fourth years at the hospital.

[25][26] In late November 2019, AdventHealth Orlando announced that it would stop paying legal guardians to take care of its incapacitated patients and would form a review panel to require two physicians to determine if patients can no longer take care of themselves before having a judge appoint a guardian.

[27][28] On March 30, 2022, AdventHealth Orlando opened a Post-COVID Clinic to treat patients having symptoms lasting 12 weeks or longer.